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. 2023 Jan 18;8(4):4331–4336. doi: 10.1021/acsomega.2c07669

Figure 1.

Figure 1

Importance of purity of a bioconjugated mPEG product. (A) Pure bioconjugate mPEG and possible impurities from side reactions and manufacturers. (B) 1H NMR spectra at 400 MHz, normalized to tetramethyl silane of ester bioconjugated mPEG 500, 2000, and 5000 Da. 1H–13C coupling is observed, peaks c* (δ = 3.82 ppm) and c** (δ = 3.47 ppm), which increase with the number of repeating units. Ester bioconjugation or ‘coupling’ peak is observed (δ = 4.28 ppm). Functional group labels refer to that in the chemical structure shown in A.