Table 8. Antitumor Activity of the Two Mixed-Ligand Complexes against Three Cancer Cell Lines.
| in vitro
cytotoxicity IC50 (μg/mL)a |
|||
|---|---|---|---|
| compounds | HePG2 | PC3 | MCF-7 |
| [Cr(OAc)(H2L1)(HL2)]·2(OAc) | 26.28 ± 1.1 | 16.64 ± 9.0 | 13.36 ± 0.8 |
| [Mn(H2L1)(HL2)]·Cl2·2H2O | 15.68 ± 1.6 | 12.44 ± 1.2 | 9.87 ± 1.0 |
| 5-FUb | 7.91 ± 0.3 | 8.22 ± 0.2 | 5.60 ± 0.2 |
a
IC50 (μg/mL): 1–10 (very strong), 11–20 (strong), 21–50 (moderate), 51–100 (weak), and above 100 (non-cytotoxic).
b
5-FU = 5-fluorouracil is the reference drug for anticancer tests.