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. 2023 Feb 1;11:15. doi: 10.1186/s40364-023-00456-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Overall structures of CD47, SIRPα and CD47 complex. A Structure of the ectodomain of human CD47 (PDB#2VSC). B Interaction of CD47 with three major ligands (SIRPα, TSP-1 and integrin). The figure was created by Biorender.com. C Complete extracellular region of human SIRPα (PDB#2WNG). The structures were reconstructed using VMD software. Abbreviations: CD47, cluster of differentiation 47; IgSF, immunoglobulin superfamily; ITIM, immunoreceptor tyrosine-based inhibitory motif; SHPS-1/2, protein tyrosine phosphatase substrate-1/2; SIRPα, signal-regulatory protein α; TSP-1: thrombospondin-1