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. 2023 Feb 1;11:15. doi: 10.1186/s40364-023-00456-x

Fig. 2.

Fig. 2

Macrophages distinguish between “self” or “non-self” by binding to SIRPα transmembrane protein on macrophage to form the CD47/SIRPα signaling complex. A CD47 expressed on cancer cell membrane binds to SIRPɑ on macrophage cell membrane to activate the “Don’t eat me” signal and block macrophage phagocytosis of cancer cells. B Blocking CD47-SIRPɑ interaction between cancer cell and macrophage induces phagocytosis by macrophage. Abbreviation: CD47, cluster of differentiation 47; SIRPα, signal-regulatory protein α