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. 2023 Feb 1;11:15. doi: 10.1186/s40364-023-00456-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Inhibiting CD47/SIRPα axis regulates the fate of cancer cells. Inhibiting the CD47/SIRPα axis can (A) directly enhance phagocytosis of macrophages to tumor cells; B transform tumor-associated macrophages into an antitumor state and increase the recruitment of macrophages in tumors; C promote phagocytosis by dendritic cells and antigen presentation to CD8 + T-cells; (D) destroy tumor cells by natural killer cell-mediated ADCC and CDC; E increase tumor cell death, inhibit tumor cell proliferation, and prevent tumor cell migration. Abbreviation: CD47, cluster of differentiation 47; SIRPα, signal-regulatory protein α; ACDD: antibody-dependent cellular cytotoxicity; CDC: complement-dependent cytotoxicity