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. 2023 Feb 2;24:40. doi: 10.1186/s12931-023-02343-3

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Correlation of lung function rate of decline and inflammatory state of the lower respiratory tract in alpha1- antitrypsin deficient individuals. A The correlation of initial FEV1 with the percentage of neutrophils, B the concentration of neutrophil elastase, and C the concentration of protease 3 (PR3) in the lower respiratory tract of alpha-1-antitrypsin deficient individuals. D The correlation of the rate of decline in lung function ( $Δ$ FEV1) with age of individuals α-1 antitrypsin deficiency, and E the concentration of neutrophil elastase, F as well as percentage of the neutrophils of the lower respiratory tract in the individuals with alpha1- antitrypsin deficiency