Table 5.
Associations between postdiagnosis strength training (arm and leg weightlifting) activity and breast cancer survival: NHS (2000-2016) and NHSII (2001-2017)a
| Outcome | MET hours of physical activity per week |
P trend | ||||
|---|---|---|---|---|---|---|
| 0 | 0 to <1.0 | ≥1.0 | ||||
| HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||
| Breast cancer–specific death (n = 215) | ||||||
| No./person-years | 140/17 020 | 50/10 611 | 25/5167 | |||
| Multivariable adjusted | Referent | 0.59 (0.33 to 1.05) | 0.51 (0.25 to 1.02) | .06 | ||
| Multivariable adjusted + prediagnosis PA | Referent | 0.60 (0.33 to 1.08) | 0.49 (0.23 to 1.06) | .07 | ||
| Overall death (n = 518) | ||||||
| No./person-years | 332/17 020 | 137/10 611 | 49/5167 | |||
| Multivariable adjusted | Referent | 0.89 (0.64 to 1.25) | 0.61 (0.39 to 0.97) | .04 | ||
| Multivariable adjusted + prediagnosis PA | Referent | 0.90 (0.64 to 1.27) | 0.65 (0.40 to 1.06) | .09 | ||
Multivariable models adjusted for estrogen receptor and progesterone receptor status, treatment with tamoxifen, aromatase inhibitor, Herceptin, and/or chemotherapy, stage at diagnosis (I-III), prediagnosis hormone therapy use, prediagnosis BMI, BMI change from prediagnosis to current, alcohol consumption, smoking status, aspirin use, and neighborhood SES. Physical activity reported at least 12 months following diagnosis with cumulative average of reported activity over follow-up. BMI = body mass index; CI = confidence interval; HR = hazard ratio; MET = metabolic equivalent task; NHS = Nurses’ Health Study; NHSII = Nurses’ Health Study II; PA = physical activity; SES = socioeconomic status.