Table 4. Association analysis for 3 target SNPs of FKBP5 gene with sleep disturbance.
| SNPs | Genotypes and alleles | Frequencies N (%) | OR (95%CI)a | P-values | |
|---|---|---|---|---|---|
| Non-sleep disturbance (n = 402) | Sleep disturbance (n = 273) | ||||
| rs1360780 | |||||
| CC | 231 (57.5) | 123 (45.1) | Ref | ||
| CT | 152 (37.8) | 100 (36.6) | 1.24 (0.86–1.73) | ||
| TT | 19 (4.7) | 50 (18.3) | 4.98 (2.80-8.84)** | ||
| C allele | 614 (76.4) | 346 (63.4) | Ref | ||
| T allele | 190 (23.6) | 200 (36.6) | 1.88 (1.48-2.39)** | ||
| HWE test for controls | 0.811 | ||||
| rs3800373 | |||||
| AA | 234 (58.2) | 156 (57.1) | Ref | ||
| CA | 149 (37.1) | 91 (33.3) | 0.92 (0.66–1.24) | ||
| CC | 19 (4.7) | 26 (9.5) | 2.06 (1.10-3.86)* | ||
| A allele | 617 (76.7) | 403 (73.8) | Ref | ||
| C allele | 187 (23.3) | 143 (26.2) | 1.18 (0.92–1.52) | ||
| HWE test for controls | 0.855 | ||||
| rs9470080 | |||||
| CC | 187 (46.5) | 140 (51.3) | Ref | ||
| CT | 170 (42.3) | 112 (41.0) | 0.88 (0.64–1.22) | ||
| TT | 45 (11.2) | 21 (7.7) | 0.63 (0.36–1.12) | ||
| C allele | 544 (67.7) | 392 (71.8) | Ref | ||
| T allele | 260 (32.3) | 154 (28.2) | 0.83 (0.66–1.06) | ||
| HWE test for controls | 0.891 | ||||
Notes.
a
Adjusted for sex, age, ethnicity, marital status, smoking status, and alcohol consumption.
*
P < 0.05.
**
P < 0.001.