Table 2:

Comparison of the laboratory parameters between baseline and eight weeks and between the two groups by using generalized estimating equation adjusted for baseline scores.

Variables	CBDEP group (n=19)		P-Value	Placebo group (n=17)		P-Value	Mean difference	95% CI	P-Value
	Baseline	8 weeks		Baseline	8 weeks
Renal function
BUN (mg/dL)	14.29±4.09	13.34±3.72	0.193	12.82±3.56	13.67±5.14	0.274	−1.63	−3.16 to−0.95	0.037*
Cr (mg/dL)	0.86±0.19	0.87±0.17	0.616	0.87±0.19	0.87±0.20	0.858	0.006	−0.34 to 0.45	0.786
Liver function
Total protein
(g/dL)	7.83±0.31	7.70±0.30	0.012*	8.07±0.48	7.98±0.30	0.005*	0.02	−0.11 to 0.15	0.749
Albumin (g/dL)	4.09±0.19	4.11±0.17	0.943	4.23±0.21	4.09±0.23	<0.001*	0.13	0.06 to 0.19	<0.001*
Globulin (g/dL)	3.74±0.31	3.59±0.29	0.001*	3.84±0.46	3.81±0.47	0.695	−0.13	−0.24 to−0.03	0.011*
Total bilirubin (mg/dL)	0.59±0.13	0.65±0.18	0.060	0.59±0.14	0.71±0.19	0.001*	−0.05	−0.12 to 0.03	0.209
Direct bilirubin (mg/dL)	0.10±0.05	0.10±0.05	0.973	0.09±0.05	0.11±0.05	0.085	−0.02	−0.05 to 0.003	0.088
Indirect bilirubin (mg/dL)	0.49±0.11	0.56±0.15	0.018*	0.51±0.12	0.59±0.15	0.002*	−0.02	−0.85 to 0.04	0.492
ALP (U/L)	77.81±30.52	66.27±18.46	<0.001*	73.74±18.49	67.46±18.85	0.013*	−4.2	−9.57 to 1.17	0.126
AST (U/L)	27.73±6.94	26.26±7.47	0.110	27.7±6.91	24.74±5.28	0.002*	1.51	−0.53 to 3.54	0.147
ALT (U/L)	20.04±7.94	16.34±7.26	<0.001*	19.84±12.60	18.05±9.90	0.074	−1.88	−3.97 to 0.21	0.078
A/G ratio	1.10±0.12	1.15±0.11	0.026*	1.12±0.15	1.09±0.15	0.073	0.08	0.03 to 0.13	0.002*

Data are presented as mean±standard deviation, *P<0.05, CBDEP, cannabidiol-enriched cannabis extraction product; CI, confidence interval; BUN, blood urea nitrogen; Cr, creatinine; ALP, alkaline phosphatase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; A/G ratio, albumin/globulin ratio.