Table 1.

Summary of results for the GWAS of depression and sex studies. Study ref. refers to the reference number of the corresponding manuscript. The replication column indicates whether the study tested for replication, failed to replicate, or replicated the association.

Chr	Gene/nearest gene	SNP	Allele	Freq	Sample size	Study Ref.	Outcome	Method	OR (SE) or β (SE)	p-value	Assoc. in males or females	Sign. Threshold	Replicated
1p12	SPAG17	rs9428240	T/C	0.41	36,078	[36]	MDD	Interaction	β: −0.18 (0.04)	1.6 × 10−7	M: β = 0.09 (0.03), p = 8.4 × 10−4; F: β = −0.09 (0.02), p = 6.4 × 10−5	5 × 10−7	No
1p12	SPAG17	rs61138090	-	0.41	23,661	[36]	Recurrent MDD	Interaction	β: −0.24 (0.05)	1.4 × 10−7	M: β = 0.14 (0.04), p = 2.1 × 10−4; F: β = −0.11 (0.03), p = 1.0× 10−4	5 × 10−7	No
2p24	LAPTM4A/SDC1	rs12471796	A/G	0.30	2206	[35]	MDD	Stratified	OR: 1.37	3.3× 10−6	Females	1 × 10−5	No
2p24	LAPTM4A/SDC1	rs7565124	A/G	0.30	2206	[35]	MDD	Stratified	OR: 1.38	3.1 × 10−6	Females	1× 10−5	No
2q24	-	rs12692709	T/C		3356	[35]	MDD	Interaction	-	5.8 × 10−6	M: β = 0.09 (0.03), p = 8.4× 10−4; F: β = −0.09 (0.02), p = 6.4× 10−5	1 × 10−5	No
3p22	CRTAP	rs4478037	A/G	0.08	43,062	[33]	MDD	Stratified	β: 0.29 (0.05)	2.3 × 10−8	Males	5 × 10−8	No
4q27	ANXA5	rs111365740	C/G	0.03	5046	[34]	Depressive symptom score*	Stratified	β: −1.86 (0.34)	3.7 × 10−8	Males	5 × 10−8	Failed to replicate
6q12	LGSN	rs9352774	C/A	0.11	1150	[35]	MDD	Stratified	OR: 1.93	2.3 × 10−6	Males	1 × 10−5	No
7q21	PCLO	rs2715148	A/C	0.48	2206	[35]	MDD	Stratified	OR: 0.74	5.6 × 10−7	Females	1 × 10−5	No
7q21	PCLO	rs2107828	A/T	0.46	2206	[35]	MDD	Stratified	OR: 0.75	2.3 × 10−6	Females	1 × 10−5	No
8p21	-	rs6993028	G/A	0.02	4832	[34]	Depressive symptom score**	Stratified	β: −2.01 (0.35)	1.3 × 10−8	Males	5 × 10−8	Failed to replicate
8q12	LOC1079 86945/FAM11OB	rs72662446	C/T	0.03	7263	[34]	Depressive symptom score*	Stratified	β: −1.85 (0.32)	6.4 × 10−9	Females	5 × 10−8	Failed to replicate
17q21	ZNF385C	rs147515485	T/C	0.02	66,534	[36]	MDD	Interaction	β: −0.47 (0.09)	4.6 × 10−7	M: β = 0.30 (0.07), p = 4.4 × 10−5; F: β = −0.19 (0.06), p = 1.6 × 10−3	5 × 10−7	No
17q25	MYO15B	rs820182	-	0.11	1000	[31]	MDD (only depressive subjects)	Difference in allele freq. by sex	OR: 1.9	1.5 × 10−5	-	5 × 10−5	No
17q25	METRNL	rs9709324	C/T	0.03	5046	[34]	Depressive symptom score*	Stratified	β: −2.08 (0.38)	4.2 × 10−8	Males	5 × 10−8	Failed to replicate
18q23	c18orf62	rs2584466	C/T	0.46	2206	[35]	MDD	Stratified	OR: 0.76	8.9 × 10−6	Females	1 × 10−5	No
19q13	ZNF285/ZFP112	rs144850488	G/A	0.05	4832	[34]	Depressive symptom score**	Stratified	β: −1.43 (0.26)	2.7 × 10−8	Males	5 × 10−8	Failed to replicate
19q13	ZNF285/ZFP112	rs17800303	C/A	0.05	4832	[34]	Depressive symptom score**	Stratified	β: −1.35 (0.24)	3.6 × 10−8	Males	5 × 10−8	Failed to replicate
19q13	ZNF285	rs113403132	G/A	0.04	4832	[34]	Depressive symptom score**	Stratified	β: −1.45 (0.25)	7.7 × 10−9	Males	5 × 10−8	Failed to replicate
19p13	SPC24	rs7251031	G/T	0.32	2206	[35]	MDD	Stratified	OR: 0.75	9.8 × 10−6	Females	1 × 10−5	No
19p13	PDE4A	rs201432982	-	0.05	1000	[31]	MDD (only depressive subjects)	Difference in allele freq. by sex	OR: 2.6	2.9 × 10−5	-	5 × 10−5	No
19p13	FDX1L/RAVER1	rs62640397	-	0.05	1000	[31]	MDD (only depressive subjects)	Difference in allele freq. by sex	OR: 2.3	3.7 × 10−5	-	5 × 10−5	No

^-= the information was not available in the paper; Depressive symptom score

^*= Depressive symptom score, after adjusting for medication use; Depressive symptom score

^**= Depressive symptom score (excl. medication users); For the association in males or females,

M = males, F = females.