. Author manuscript; available in PMC: 2023 Feb 2.

Published in final edited form as: Neuroimage Rep. 2022 Nov 18;2(4):100146. doi: 10.1016/j.ynirp.2022.100146

Table 2.

Correlations between chronological age, Brain Predicted Age Difference (BrainPAD) and key physiological metrics.

	Chronological Age	Brain Predicted Age	BrainPAD (adjusted for chronological age)
Chronological Age		0.555 (<0.001)
BMI (kg/m²)	−0.138 (0.001)	− 0.037 (0.392)	0.048 (0.257)
Body Fat Percentage (%)	−0.128 (0.003)	− 0.064 (0.136)	0.008 (0.850)
Visceral Adipose Tissue (kg)	0.012 (0.773)	0.132 (0.002)	0.152 (<0.001)
Resting Heart Rate (bpm)	0.014 (0.75)	0.011 (0.796)	0.004 (0.924)
Estimated Maximal Capacity (METS)	−0.285 (<0.001)	−0.259 (<0.001)	−0.127 (0.003)
Total Physical Activity (counts/min)	−0.177 (<0.001)	−0.147 (<0.001)	− 0.062 (0.150)
Total Sleep Time (hours)	0.114 (0.008)	0.134 (0.002)	0.087 (0.042)
Sleep Efficiency (%)	0.064 (0.137)	0.06 (0.165)	0.030 (0.483)
Education (years)	− 0.49 (0.258)	0.02 (0.65)	0.055 (0.199)
APOE E4 genotype (yes/no)	− 0.17 (0.7)	0.03 (0.488)	0.013 (0.760)

All values presented as Pearson’s Correlation Coefficient (r) and p value of association BMI=Body Mass Index; VAT=Visceral Adipose Tissue; METS= Metabolic Equivalent of Task; bpm= beats per minute.