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. Author manuscript; available in PMC: 2023 Oct 7.
Published in final edited form as: ACS Catal. 2022 Sep 19;12(19):12014–12026. doi: 10.1021/acscatal.2c03743

Table 1.

Conventional Site Selectivity for Substrates Discussed in this Perspective.

graphic file with name nihms-1867334-t0007.jpg
Substrate Total Examplesa Percentage of Examples with Conventional Selectivity (%)b Percentage of Examples with PPh3 or dppf (%)c
1 186 81 43
2 143 92 81
3 822 97 77
4 77 94 52
5 68 (56) 50
6 164 93 49
7 223 99 52
8 162 88 36
9 1284 99 92
10 23 (57) 22
11 15 100 40
12 11 (55) 36
13 1 (100) 0
14 59 100 78
15 222 100 66
a

Total number of examples of Pd-catalyzed cross-coupling to form a C—C or C—N bond, according to a SciFinder search.5

b

Percentage of examples for which the major product is indicated to result from coupling at the highlighted position. Values in parentheses indicate that the literature is near-evenly divided in describing selectivity or the number of examples is too small to evaluate.

c

Percentage of examples for which PPh3 or dppf were included in the reaction conditions.