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. 2022 Nov 29;119(49):e2208254119. doi: 10.1073/pnas.2208254119

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Copyright © 2022 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — OLM behavioral expression is dependent on catecholaminergic receptor activation; however, DA D1/D5 receptor activation modulates OLM memory updating. A. Cannula implantation in the hippocampal CA1 for pharmacological dosing. B. Histology of coronal brain sections of the hippocampal CA1 region with a cannula. C. OLM protocol. D. Recognition index in the update and test sessions with an object in the familiar location (FL) and the novel location (NL) in mice infused with ISS (n = 11), SCH (n = 9), or PROP (n = 12) before the update session. E. Recognition index in the update and test sessions in mice infused with ISS (n = 10), SCH (n = 12), or PROP (n = 9) after the update session. All results show the mean recognition index ± SEM. ***P < 0.001; **P < 0.01.