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. 2022 Dec 2;119(49):e2207181119. doi: 10.1073/pnas.2207181119

Table 1.

ANOVA model evaluation for GMV

GMV ~
Model Null Age Age + Sex Age + Sex + CyClo
CyClo2 ***
Sex *** ***
Age *** *** ***
Constant *** *** *** ***
AICBIC −4,875 −5,129 −5,188 −5,201
−4,860 −5,109 −5,163 −5,171

Parameter selection tests. The linear mixed-effects model with the smallest AIC and BIC score is model 4 that takes into account all 3 parameters (age, sex, and CyClo). ANOVA of models 3 and 4 returns significant P < 0.001***.

Random effect = subject ID.

*P < 0.05; **P < 0.01; ***P < 0.001.