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. 2022 Nov 29;119(49):e2206722119. doi: 10.1073/pnas.2206722119

Fig. 2.

Fig. 2.

Maps and models of nucleotides in active sites of Arps and actin in the branch junction. (A) ADP in the active site of Arp3 without density for inorganic phosphate. The side chain of H192 is in an inactive conformation, similar to H161 in actin monomers. (B) ATP in the active site of Arp2 in spite of the catalytic residues Q137 and H161 being in active conformations. The distance from Q137 Cδ to ATP Pγ is 5.1 Å and that from H161 Nε2 to ATP Pγ is 6.2 Å; counterparts in the AMPPNP-actin filament are 4.7 Å and 6.7 Å. (C) ADP in the active site of mother filament actin subunit M1.