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. 2022 Dec 1;119(49):e2215124119. doi: 10.1073/pnas.2215124119

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Copyright © 2022 the Author(s). Published by PNAS.

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — The template complexes proofread Qbc-SNARE binding. (A) FECs showing specific Qbc SNARE (SNAP-25 or SNAP-23) binding to its cognate template complex containing either Munc18-1 or Munc18-3. The Qbc-SNARE binding probabilities and associated total numbers of tests are shown in pairs in parenthesis. Reversible CTD transitions are marked by magenta dashed ovals. (B and C) Extension-time trajectories at constant mean force showing folding and unfolding transitions of the CTDs (B) or template complexes (C). The Qbc-SNARE binding events are indicated by red arrows.