FIG. 2.

Birth, life, and death of Cln3. An outline of processes influencing the synthesis, activation, and destruction of Cln3 is shown. Heavy, open arrowheads indicate transitions involving CLN3 and its gene product. Lighter, solid arrowheads denote cellular components and environmental influences that positively regulate the indicates tep. T-shaped lines denote cellular components and environmental influences that negatively regulate the indicated step. The circled “P” indicates a phosphorylated protein, “ubi-” indicates a ubiquitinated protein. Indicated relationships may be indirect, and some steps are speculative. See the text for details.