TABLE 7.
Putative destruction box sequences in selected yeast APC substrates
| Substrate (residues) | Destruction box sequenceb | Reference(s) |
|---|---|---|
| Clb1 (35–43) | RTILGNVTN | 181 |
| Clb2 (25–33) | RLALNNVTN | 181 |
| Clb3 (51–59) | RVALSRVTN | 181 |
| Clb4 (43–51) | RVALGDVTS | 181 |
| Clb5 (56–64) | RALTDVPVN | 160, 310, 487 |
| Cdc5 (17–25) | RSKLVHTPI | 503 |
| Cdc5 (61–69) | RKKLSALCK | 503 |
| Cdc20 (17–25) | RSVLSIASP | 449, 503 |
| Cdc20 (60–68) | RPSLQASAN | 449, 503 |
| Pds1 (85–93) | RLPLAAKDN | 96, 623 |
| Cyclin A consensusa | RxALGVzxN | 199 |
| Cyclin B consensusa | RxALGyzxN | 199 |
a
x is any amino acid; y is N, D, or E; and z is either I, V, or L.
b
Boldface indicates conserved residues in yeast which match those of metazoan consensus sequences.