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. 2023 Jan 23;21(1):e3001950. doi: 10.1371/journal.pbio.3001950

Fig 8. Model for misfolded membrane protein-induced toxicity.

Fig 8

A model depicting how accumulation of ER-resident misfolded membrane proteins would induce growth toxicity. (1) No growth toxicity is observed when misfolded membrane proteins aggregate but are not ubiquitinated. (2) No growth toxicity is observed when misfolded membrane proteins are ubiquitinated, but not aggregated. (3) Growth toxicity is observed when misfolded membrane proteins are both ubiquitinated and aggregated. ER, endoplasmic reticulum.