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. 2022 Jun 10;3(5):428–443. doi: 10.1158/2643-3230.BCD-21-0075

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) license.

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Figure 6. — Association between tumor MHCII status and tumor-infiltrating T-cell populations. A, A bar graph shows the fold change in cellular fractions of CD8 and CD4 T-cell populations between MHCII-low and MHCII-high tumors, colored by Fisher exact FDR q-value. The CD8_Exh (fold change 3.43, Fisher exact q = 0.05) and CD4_CTL (fold change 2.11; Fisher exact q = 0.07) populations are significantly higher in MHCII-high tumors compared with MHCII-low tumors. B, UMAP density plots show the relative representation of CD8_Exh between MHCII-low (above) or MHCII-high (below) tumors. C, Scatter plot and bar plot show the quantitative and qualitative association between CD8_Exh population and either the expression or status of MHCII on tumor B cells, respectively. D, UMAP density plots show the relative representation of CD4_CTL, between MHCII-low (above) or MHCII-high (below) tumors. E, Scatter plot and bar plot show the quantitative and qualitative association between CD4_CTL population and either the expression or status of MHCII on tumor B cells, respectively. F, IHC staining of HLA-DR was used to assign tumors into high (2), low (0–1), and reactive (R) groups, which were evaluated for the intrafollicular density of CD3⁺CD4⁺GZMK⁺ cytotoxic CD4 T cells. P values between MHCII-high and -low groups were calculated using a one-tailed t test.