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. Author manuscript; available in PMC: 2023 Feb 2.
Published in final edited form as: Nat Genet. 2022 Jun 6;54(6):827–836. doi: 10.1038/s41588-022-01087-y

Figure 1: Overview of S2G framework.

Figure 1:

(a) Toy example of SNP linked to two genes (arrow widths denote linking scores). (b) Toy example of h2 coverage. Strategy 1 (which links SNPs with larger effects on disease) has more h2 coverage than strategy 2, which has more h2 coverage than strategy 3 (which links SNPs with smaller effects on disease). (c) Toy example of using critical gene sets to define precision. Strategy 1 (which links the middle SNP with high effect on disease to the gene from the critical gene set) is more precise than strategy 2 (which links the middle SNP to both genes), which is more precise than strategy 3 (which links the middle SNP to the gene that is not from the critical gene set). Recall is defined as the product of the h2 coverage and precision. (d) Toy example of combined S2G strategy. The combined S2G strategy is a linear combination of constituent S2G strategies.