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Sequences of PIK3CB mRNA (on-target), AM1-modified siRNA guide strands, YY1 and FADD off-target mRNAs (off-target), and phosphoramidite building blocks to introduce AM1 modification. ‘G’ denotes guide strand targeting PIK3CB and the number denotes the position of AM1 modification; ‘p’ denotes phosphodiester and ‘a’ denotes amide internucleoside linkages; the mismatched nucleotides in YY1 and FADD sequences are highlighted in pink.
