Figure 3.

Dual-luciferase assay IC₅₀ values of unmodified (G0) and AM1-modified (G2-G20) siRNAs targeting PIK3CB (A), YY1 (B), and FADD (C). # indicates that IC₅₀ values for G3 targeting YY1 and G2 and G3 targeting FADD could not be calculated because the expression did not go below 60% at the maximum concentration (20 nM); when comparing the data with G0, * and ** indicate two-tailed P values of less than 0.05 and 0.01, respectively, as calculated using Student’s t-test.