TABLE 2.

Neurodevelopmental impairment (NDI) studies of Necrotizing enterocolitis (NEC) among preterm infants.

References	Centers	Assessment tool	Birth weight (g) [mean (range) of NEC]	Duration of follow up (months corrected age)	Number with NEC attended follow-up (n)	Total number of attended follow-up (n)	Definitions of NDI
Shah et al., 2012	Multi	BSID II	ELBW	Hospital discharge, 18 and 22 months	62	785	NDI: at least include 1 of the following: MDI < 70, PDI < 70, CP, hearing impairment, visual impairment
Hintz et al., 2005	Multi	BSID II	ELBW	18,22	245	2,703	NDI: at least include 1 of the following: MDI < 70, PDI < 70, CP, blindness, deafness.
Zozaya et al., 2021	Multi	BSID-III	ELBW	18–30	176	2,019	NDI:CP with GMFCS score, Bayley-III component score of < 85, hearing loss, or visual impairment
Hansen et al., 2019	Single	Strength and Difficulties score	1442.5	126	163	400	Borderline/abnormal SDQ-score; CP
Wadhawan et al., 2014	Multi	BSID-II; Amiel-Tison assessment	ELBW	18–22	472	8,938	moderate or severe cerebral palsy, bilateral blindness, bilateral hearing loss needing amplification, MDI or PDI less than 70
Lodha et al., 2010	Two	BSID-II	1,145	24–28	10	40	NDI: Includes MDI < 70, PDI < 70, and CP.
Dilli et al., 2012	Single	BSID-II	VLBW	18–24	20	60	moderate-to-severe cerebral palsy; MDI or PDI < 70; bilateral deafness; or bilateral blindness.
Sonntag et al., 2000	Single	Griffiths	VLBW	12,20	20	60	NDI: GQ < 2 SDs below mean
Salhab et al., 2004	Single	BSID-II	ELBW	18–22	17	68	No clear definition. Data on mean MDI and PDI given
Soraisham et al., 2006	Single	BSID-II and Stanford- Binet	BW below 1,250 g	36	46	146	NDI: at least include 1 of the following: cognitive delay (MDI or IQ < 2 SDs below mean), CP, visual impairment, deafness.
Roze et al., 2011	Single	Movement-ABC; WISC-III-NL; Child Behavior Checklist	1,020 –1,775	6–13 Year	32	83	Data on mean Motor outcome, Cognitive outcome and Behavioral outcome are given
Allendorf et al., 2018	Single	BSID-II	1,039	24	37	76	No clear definition. Data on mean MDI and PDI given
Martin et al., 2010	Multi	BSID-II	n/a, 23–27 weeks gestation	24	101	1,155	moderate-to-severe cerebral palsy; MDI or PDI < 70;
Fullerton et al., 2017	Multi	BSID-II or BSID-III	ELBW	18–24	866	9,929	Severe neurodevelopmental disability: bilateral blindness, hearing impairment requiring amplification, inability to walk 10 steps with support, cerebral palsy, and/or Bayley Mental or Psychomotor Developmental Index < 70.
Pike et al., 2012	Multi	Health Utilities Index (HUI)and Strength and Difficulties score	n/a	7Y	119	6,615	Based on HUI-3 classification
Castro et al., 2004	Multi	BSID-II	ELBW	18–22	72	1,151	NDI: Includes MDI < 70, PDI < 70, and CP.
Chacko et al., 1999	Single	Griffiths and Stanford-Binet	ELBW	12–59	40	60	NDI: at least include 1 of the following: GQ or IQ < 71, moderate or severe CP, blindness, deafness
Waugh et al., 1996	Single	Griffiths and McCarthy Index	ELBW	24	23	198	NDI: GQ < 76 (2 SDs below mean), CP, Visual impairment, Deafness
Tobiansky et al., 1995	Single	Griffiths and Stanford-Binet	VLBW	36–60	49	89	NDI: at least include 1 of the following: GQ or IQ < 71, moderate or severe CP, blindness, deafness
Mayr et al., 1994	Single	Denver test, drawing test	VLBW	12–156	12	18	No clear definition
Simon et al., 1993	Single	BSID I	VLBW	8,15,24	18	18	No clear definition. Data on mean MDI and PDI given
Ganapathy et al., 2013	Multi	n/a	All neonates	6, 12, 24,36	250	2,899	No clear definition
Hayakawa et al., 2015	Multi	n/a	VLBW	18	44	394	NDI was defined as the presence of neurological sequelae in infants at 18 months of corrected age.

NDI, neurodevelopmental impairment; n/a, data is not available in respective studies; BSID, Bayley Scales of Infant and Toddler Development; WISC-III-NL, Wechsler Intelligence Scale for Children, third edition, Dutch version.