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. Author manuscript; available in PMC: 2024 Jan 1.
Published in final edited form as: FEBS Lett. 2022 Oct 27;597(1):92–101. doi: 10.1002/1873-3468.14519

Figure 6. Photoinduced electron transfer of SAM bound to [4Fe-4S]+ clusters.

Figure 6.

Photoinduced electron transfer of SAM bound to [4Fe-4S]+ clusters in a range of radical SAM enzymes results in cleavage of either the S-C5´ bond to generate 5´-dAdo•, or the S-CH3 bond to generate •CH3, with the radicals cryotrapped in the active site (left). The regioselectivity of photoinduced S-C bond cleavage correlates with the SAM ribose ring pucker (upper right) and is explained by the Jahn-Teller effect on the one-electron reduced sulfonium radical (right).