Table 3.
The combined effect of risk alleles of 2 most significant associations (rs60970102 and rs77480547) with CM OS detected in the GWAS study, assuming an additive genetic model and categorizing by risk groups.
| Combined risk alleles (CRA) | N (%) | Additive genetic model | Stratified by risk groups | ||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | P-value* | Risk Groups | N deaths (%) | HR (95% CI) | P-value* | ||
| 0 | 711 (76.3) | 2.99 (2.24–3.98) | 9.21×10-14 | Low | 58 (8.2) | Ref. | Ref. |
| 1 | 196 (21.0) | Medium | 36 (18.4) | 3.64 (2.33–5.69) | 1.43×10-8 | ||
| 2 | 23 (2.5) | High | 9 (36.0) | 8.30 (3.99-17.27) | 1.48×10-9 | ||
| 3 | 2 (0.2) | ||||||
| p-trend | 2.18×10-13 | ||||||
* Models adjusted for age at diagnosis, sex, tumor stage, tumor anatomic sites, and top 3 PCs. In the additive genetic model, the composite germline risk alleles (CRA) was treated as a continuous variable. We further categorized patients based on their CRA scores (low risk CRA=0, medium risk CRA=1, and high risk CRA >1), and tested for the association of the combined effect on OS with low risk group as reference. Individuals with the highest number of CRA has the highest risk of death as reflected by both percentage of death and HR in the high risk group compared to medium and low risk. P-trend: p-value of trending significance assuming the three risk groups as continuous variables.