Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 12;8(2):246–259. doi: 10.1038/s41564-022-01293-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 5 — a, Box and swarm plots (line, median; box, IQR; whiskers, 1.5*IQR) of the levels of metabolites associated with sPTB, comparing preterm and term deliveries and stratifying by maternal self-identified race. P – two-sided Mann-Whitney U. b, Distribution (kernel density estimation) of four xenobiotics associated with sPTB or early sPTB across this cohort. Samples with no metabolite detected are excluded. c, Same as Fig. 2a, for women not treated with progesterone. d, Heatmap showing metabolite sets altered in sPTB in various subsets of this cohort. Colors correspond to two-sided p-value of metabolite set enrichment analysis (Methods). Only associations with FDR < 0.1 are shown. e, Raw intensity levels measured across samples for the same four xenobiotics as in b, compared to measures from plate negative process controls. Box mid-line, median; box, IQR; whiskers, 1.5*IQR; vertical line, min:max range; dot, mean; N.D., not detected. N = 232 for Diethanolamine; N = 230 for ethyl glucoside; N = 221 for tartrate; N = 232 for EDTA. f, Mass error for spectral matching (y-axis) for the same xenobiotics, compared to the mean mass error for all non-xenobiotic, tier 1 metabolites, showing that the four xenobiotic metabolites had very good identification quality.