TABLE 4.
Yop proteins involved in translocation
| Protein | Size (kDa) | Structural featuresa | Role(s) | Relevant similarities | References |
|---|---|---|---|---|---|
| YopB | 41.8 | Central hydrophobic domains (aa 168–208 and aa 224–258); coiled coils (aa 103–165 and aa 330–385) | Needed for translocation; needed for contact hemolysis; hypothetical constituent of a pore | RTX toxin (LktA, HlyA, …); IpaB (S. flexneri); PopB (P. aeruginosa); YopD; EspB (EPEC); SipB (S. typhimurium) | 41, 136, 138, 146, 183, 190, 224, 321, 379 |
| YopD | 33.3 | Central hydrophobic domain (aa 122–152); coiled coils (aa 249–292); C-terminal amphipathic α-helix | Needed for translocation | PopD (P. aeruginosa); YopB | 41, 136, 259, 321, 379 |
| LcrV | 37.2 | Polymorphism | Required for extrusion of YopB and YopD | PcrV (P. aeruginosa) | 270, 276, 294, 379 |
| YopK/YopQ | 20.8 | None | Controls translocation by modulating the size of the YopB-induced pore | None | 161, 162 |
a
aa, amino acids.