TABLE 6.
Yop effectors
| Protein | Size (kDa) | Action on the cell | Enzymatic activity | Relevant similarities | Localization in the target cell | Sufficient signals fora:
|
Reference(s) | |
|---|---|---|---|---|---|---|---|---|
| Secretion (aa or codons) | Translocation (aa) | |||||||
| YopE | 22.9 | Disruption of the cytoskeleton; rounding up of cells; detachment from extracellular matrix | Cytotoxicity | ExoS (P. aeruginosa); SptP/StpA (Salmonella) | Perinuclear region | 11 | 50 | 10, 14, 184, 282, 283, 300, 321, 378 |
| YopH | 51.0 | Disruption of peripheral focal complexes | PTPase | Eukaryotic phosphatases; SptP/StpA (Salmonella) | Cytoplasm | 17 | 71 | 14, 31, 32, 46, 132, 184, 258, 321, 340 |
| YopM | 41.6 | Unknown | Unknown | y4fR (Rhizobium); IpaH (Shigella); numerous proteoglycans; GP1bα | Unknown | 40 | 100 | 41, 104, 148, 207, 208 |
| YpkA/YopO | 81.7 | Rounding up of cells | Ser/Thr kinase | Ser/Thr kinases; COT oncogene | Inner surface of plasma membrane | 77 | 77 | 74, 110, 137, 324 |
| YopP/YopJ | 32.5 | Apoptosis of macrophages; inhibition of TNF-α release | Cytotoxicity | AvRxv (X. campestris); AvrA (Salmonella) | Cytoplasm | 99 | 99 | 41, 144, 232, 237, 251, 324 |
| YopT | 35.5 | Disruption of actin filaments | Cytotoxicity | p76 (H. somnus) | Unknown | 124 | 124 | 170 |
a
aa, amino acids.