表 2.
IgA肾病患者和健康对照者肠道菌群的相对丰度变化
Change in relative abundance of gut microflora in IgA nephropathy patients and health controls
| Items | IgA nephropathy (n=19), M (min, max) | Controls (n=15), M (min, max) | P |
| Phylum | |||
| Bacteroidetes | 3.13×10-1 (3.86×10-2, 7.65×10-1) | 4.13×10-1 (8.29×10-2, 8.61×10-1) | 0.046 |
| Actinobacteria | 2.47×10-2 (6.84×10-4, 1.91×10-1) | 2.59×10-3 (2.63×10-4, 7.52×10-2) | 0.001 |
| Lentisphaerae | 0 (0, 2.93×10-5) | 0 (0, 6.81×10-3) | 0.011 |
| Saccharibacteria | 5.07×10-5 (0, 6.40×10-4) | 0 (0, 4.25×10-5) | < 0.001 |
| Genus | |||
| Escherichia-Shigella | 2.88×10-3 (7.79×10-5, 3.88×10-1) | 3.79×10-4 (0, 6.38×10-2) | 0.025 |
| Bifidobacterium | 1.17×10-2 (2.409×10-5, 1.87×10-1) | 1.15×10-3 (5.42×10-5, 6.84×10-2) | 0.036 |
| Lachnospira | 1.43×10-3 (0, 1.82×10-2) | 1.73×10-2 (0, 1.25×10-1) | 0.002 |
| Dorea | 8.84×10-3 (7.77×10-4, 1.03×10-1) | 4.67×10-3 (1.29×10-3, 1.07×10-2) | 0.025 |
| Erysipelotrichaceae_UCG-003 | 7.42×10-3 (0, 1.65×10-1) | 1.75×10-3 (1.78×10-4, 3.03×10-2) | 0.013 |
| Coprococcus_2 | 0 (0, 8.76×10-3) | 3.97×10-3 (0, 4.59×10-2) | 0.028 |
| Sutterella | 0 (0, 1.87×10-3) | 3.73×10-3 (0, 4.08×10-2) | < 0.001 |
| Tyzzerella_3 | 0 (0, 2.52×10-2) | 2.90×10-3 (0, 1.61×10-2) | 0.012 |
| Thalassospira | 0 (0, 1.73×10-3) | 0 (0, 5.52×10-2) | 0.015 |
| Lachnospiraceae_UCG-004 | 2.78×10-4 (0, 5.13×10-3) | 2.50×10-3 (2.93×10-4, 1.27×10-2) | 0.001 |
| Eubacterium_ventriosum_group | 3.04×10-4 (0, 1.02×10-2) | 1.31×10-3 (2.13×10-5, 1.27×10-2) | 0.042 |
| Lachnospiraceae_ND3007_group | 1.37×10-4 (0, 1.95×10-3) | 1.68×10-3 (2.44×10-5, 1.08×10-2) | 0.002 |
| Eggerthella | 1.11×10-3 (0, 1.23×10-2) | 0 (0, 6.58×10-5) | < 0.001 |
| Ruminiclostridium_5 | 8.97×10-4 (7.78×10-5, 7.58×10-3) | 4.14×10-4 (0, 1.34×10-3) | 0.030 |
| Lachnospiraceae_UCG-010 | 5.06×10-5 (0, 3.48×10-3) | 5.72×10-4 (0, 2.68×10-3) | 0.049 |
| Butyricimonas | 2.60×10-5 (0, 1.86×10-3) | 3.73×10-4 (0, 8.27×10-3) | 0.013 |
| Flavonifractor | 2.63×10-4 (0, 5.19×10-3) | 2.96×10-5 (0, 6.30×10-4) | 0.035 |
| Desulfovibrio | 0 (0, 1.82×10-3) | 0 (0, 1.25×10-2) | 0.045 |
| Ruminococcaceae_UCG-003 | 2.60×10-4 (0, 7.00×10-4) | 4.44×10-4 (4.25×10-5, 3.12×10-3) | 0.006 |
| Terrisporobacter | 2.53×10-5 (0, 8.71×10-3) | 0 (0, 6.58×10-4) | 0.003 |
| Granulicatella | 0.30×10-5 (0, 6.34×10-3) | 0 (0, 5.72×10-5) | 0.003 |
| Erysipelatoclostridium | 4.05×10-5 (0, 3.34×10-3) | 0 (0, 5.48×10-5) | 0.009 |
| Ruminiclostridium_9 | 2.16×10-5 (0, 1.19×10-3) | 2.36×10-4 (0, 1.14×10-3) | 0.015 |
| Victivallis | 0 (0, 2.93×10-5) | 0 (0, 6.81×10-3) | 0.011 |
| Cercis_gigantea | 2.53×10-5 (0, 4.07×10-3) | 0 (0, 3.33×10-5) | 0.015 |
| Ezakiella | 0 (0, 3.88×10-3) | 0 (0, 2.74×10-5) | 0.021 |
| Family_XIII_UCG-001 | 0 (0, 6.07×10-4) | 6.91×10-5 (0, 3.52×10-4) | 0.042 |
| Rothia | 0 (0, 2.47×10-3) | 0 (0, 8.91×10-5) | 0.030 |
| Gemella | 3.00×10-5 (0, 1.45×10-3) | 0 (0, 8.26×10-5) | 0.001 |
| Solobacterium | 2.16×10-5 (0, 7.25×10-4) | 0 (0, 3.33×10-5) | 0.045 |
| Acinetobacter | 0 (0, 2.13×10-4) | 0 (0, 2.74×10-5) | 0.028 |
| Corynebacterium | 0 (0, 2.13×10-4) | 0 (0, 0) | 0.005 |
| Olsenella | 2.16×10-5 (0, 8.09×10-5) | 0 (0, 3.33×10-5) | 0.007 |
| Atopobium | 0 (0, 1.20×10-4) | 0 (0, 0) | 0.035 |
| Leptotrichia | 0 (0, 1.20×10-4) | 0 (0, 0) | 0.010 |
| Methylobacterium | 0 (0, 8.69×10-5) | 0 (0, 0) | 0.019 |