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. 2023 Feb 2;14:563. doi: 10.1038/s41467-023-36160-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A Workflow for NK isolation and UNC0642 treatment during NK cell expansion. Created with BioRender.com. B Granzyme B expression levels in NK cells after UNC0642 treatment (n = 3 donors). C Example normalized cell index for 2D cytotoxicity assay for untreated and UNC0642-treated NK cells. D Area under the curve for the normalized cell index for the 2D cytotoxicity assay as shown in example plot in C. Data for untreated and UNC0642-treated NK cells at 1:2, 1:4 and 1:8 effector:target ratio are shown. Data are analyzed with one-way ANOVA with multiple comparisons. (n = 3 donors). E Normalized live target cell count for the 3D cytotoxicity assay for target cells after addition of untreated or UNC0642-treated NK cells (n = 3 donors, each data point represents an analyzed ROI). Data are analyzed with one-way ANOVA with multiple comparisons. Data shown are for four different donors. All data are shown as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Source data are provided as a Source Data file.