TABLE 5.

The association between severity of depressive symptoms and serum level of inflammatory markers.

Inflammatory markers	N	Goodness of fit (value/df)	Omnibus Test (P值)	BDD1
				Mild				Moderate				Severe
				β2	95%CI		P 3	β2	95%CI		P 3	β2	95%CI		P 3
WBC4	156	3.312	0.463	−0.409	−1.606	0.789	0.504	0.037	−0.793	0.868	0.930	0.400	−0.241	1.042	0.221
CRP5	172	0.951	0.535	−0.121	−0.691	0.449	0.677	−0.175	−0.593	0.243	0.412	−0.225	−0.535	0.085	0.155
ADP5	210	1.612	0.013	−0.482	−1.149	0.185	0.157	−0.481	−0.928	−0.034	0.035	−0.557	−0.915	−0.199	0.002
LEP5	210	1.591	0.113	−0.295	−0.0959	0.368	0.383	0.188	−0.257	0.632	0.407	−0.330	−0.686	0.026	0.069
VIS5	210	1.322	0.512	−0.255	−0.866	0.357	0.414	−0.218	−0.627	0.191	0.297	−0.217	−0.545	0.111	0.196
MCP-15	210	1.730	<0.001	−0.904	−1.592	−0.215	0.010	−0.733	−1.194	−0.272	0.002	−0.810	−1.179	−0.440	< 0.001
IL-25	156	0.794	0.392	−0.048	−0.552	0.457	0.853	−0.162	−0.530	0.205	0.386	0.153	−0.156	0.462	0.331
IL-65	210	1.914	<0.001	−1.087	−1.807	−0.366	0.003	−0.928	−1.410	−0.446	<0.001	−0.544	−0.930	−0.158	0.006
IL-105	210	1.665	0.001	−1.069	−1.746	−0.393	0.002	−0.581	−1.034	−0.128	0.012	−0.616	−0.979	−0.253	0.001
IL-175	156	1.197	<0.001	−1.203	−1.810	−0.595	<0.001	−1.035	−1, 0.478	−0.593	<0.001	−1.235	−1.607	−0.863	< 0.001
TNF-α5	210	1.215	0.405	−0.106	−0.694	0.483	0.725	−0.319	−0.714	0.075	0.112	0.027	−0.288	0.343	0.865
N/L6	154	0.206	0.328	−0.182	−0.476	0.113	0.226	0.003	−0.201	0.208	0.975	0.087	−0.071	0.246	0.280
IL-2/IL-105	156	0.921	0.403	0.382	−0.157	0.922	0.165	−0.024	−0.417	0.369	0.904	0.162	−0.169	0.493	0.337
IL-6/IL-105	210	1.584	0.032	−0.892	−1.554	−0.230	0.008	−0.361	−0.805	0.082	0.110	−0.368	−0.724	−0.013	0.042
IL-17/IL-105	156	0.978	0.001	−0.319	−0.874	0.235	0.257	−0.296	−0.699	0.108	0.151	−0.752	−1.091	−0.412	< 0.001

¹Adjustment for age, gender, marital status, BMI, education, and severity of manic symptoms.

²Taking the healthy control group as reference, if the β is positive, the level of inflammatory marker is higher than that of healthy control group, and if the β is negative, the level of inflammatory marker is lower than that of healthy control group.

³Bold font denotes p < 0.05/15 = 0.0033.

⁴According to the scatter plot and statistical test, these data are approximately normally distributed, so the linear model is used in modeling.

⁵According to the scatter plot and statistical test, these data are skewed distributed, but approximately normally distributed after log conversion, so gamma with log link model is chosen for modeling.

⁶N/L: Granulocyte/lymphocyte ratio.