TABLE 3.
Univariate analysis for severe cases regarding to different SNPs genotype and allele.
| SNPs genotypes and alleles | Severe vs. mild® | Severe vs. control® | ||
|---|---|---|---|---|
| p | OR (LL–UL 95% CI) | p | OR (LL–UL 95% CI) | |
| HLA-DQrs7453920 (A/G) | ||||
| GG® | 1.000 | 1.000 | ||
| AG | 0.371 | 1.5 (0.6–3.4) | 0.158 | 1.8 (0.8–4.2) |
| AA | <0.001 a | 12.9 (4.6–36.1) | <0.001 a | 24.4 (7.7–77.4) |
| Allele | ||||
| G® | 1.000 | 1.000 | ||
| A | <0.001 a | 3.7 (2.3–5.8) | <0.001 a | 4.6 (2.9–7.3) |
| HLA-DPrs3077 (G/A) | ||||
| AA® | 1.000 | 1.000 | ||
| GA | 0.562 | 1.6 (0.3–8.4) | 0.537 | 1.7 (0.3–8.4) |
| GG | <0.001 a | 16.4 (3.5–77.4) | <0.001 a | 34 (7.1–163) |
| Allele | ||||
| A® | 1.000 | 1.000 | ||
| G | <0.001 a | 7.3 (3.9–13.8) | <0.001 a | 10.4 (5.56–19.6) |
| IFNλ4rs73555604 (C/T) | ||||
| TT® | 1.000 | 1.000 | ||
| CT | 0.456 | 1.5 (0.5–4) | 0.193 | 1.9 (0.7–5.2) |
| CC | <0.001 a | 9.5 (3.4–26.8) | <0.001 a | 11.4 (4.1–31.7) |
| Allele | ||||
| T® | 1.000 | 1.000 | ||
| C | <0.001 a | 3.8 (2.3–6.1) | <0.001 a | 4.2 (2.6–6.8) |
a
Statistically significant at p ≤ 0.05.
OR, Odd’s ratio; ®, Reference group; CI, confidence interval; LL, lower limit; UL, upper limit; p, p-value for univariate regression analysis for comparing with the reference genotype.