Fig. 5. Area under the curve (AUC) analysis on a receiver operating characteristic (ROC) curve representing the discriminative ability of four miRNAs associated with pheno-conversion (miR-4505, miR-8069, miR-6125, and miR-451a) when comparing DaT-positive L2NMC non-pheno-converted after 8 years of follow-up (n = 16) vs. all pheno-converted subjects, i.e., L2PD discovery (n = 20) and validation (n = 19) sets, and DaT-positive L2NMC diagnosed with PD during the study (n = 4) (total n = 43).

DaT DaT-SPECT imaging, L2NMC LRRK2 non-manifesting carriers, L2PD LRRK2-associated PD patients.