Table 2.
RT-qPCR assessment of miRNA levels in serum samples from DaT-negative and DaT-positive L2NMC, L2PD patients and iPD as compared to healthy controls.
| MicroRNA | DaT (−) L2NMC (n = 20) | DaT (+) L2NMC (n = 20) | L2PD (n = 20) | iPD (n = 19) | ||||
|---|---|---|---|---|---|---|---|---|
| FC | Adj. p | FC | Adj. p | FC | Adj. p | FC | Adj. p | |
| miR-122-5p | 7.07 | 3.0 × 10−6 | 3.38 | 0.0269 | 2.01 | 0.1616 | 3.05 | 0.0025 |
| miR-16-5p | 3.42 | 0.0007 | 2.51 | 0.0237 | 1.66 | 0.2590 | 5.21 | 0.0003 |
| miR-185-5p | 3.68 | 3.0 × 10−5 | 4.32 | 0.0004 | 1.49 | 0.3122 | 3.60 | 0.0028 |
| miR-19b-3p | 1.05 | 0.8394 | 1.25 | 0.5280 | −2.05 | 0.1303 | 3.04 | 0.0018 |
| miR-22-3p | 1.66 | 0.0632 | 1.77 | 0.0759 | 1.64 | 0.1611 | 2.67 | 0.0025 |
| miR-221-3p | 2.06 | 0.0079 | 1.15 | 0.6263 | 1.37 | 0.3122 | 1.93 | 0.0076 |
| miR-29c-3p | 1.44 | 0.1435 | 1.93 | 0.0759 | 1.45 | 0.2741 | 2.67 | 0.0025 |
| miR-3196 | 2.43 | 1.0 × 10−5 | 1.98 | 0.0012 | 2.13 | 0.0001 | 1.11 | 0.6142 |
| miR-4505 | 1.98 | 0.0016 | 3.51 | 0.0004 | −1.06 | 0.7803 | −1.28 | 0.3225 |
| miR-451a | 4.44 | 1.1 × 10−5 | 4.16 | 0.0004 | 2.43 | 0.0629 | 4.76 | 0.0016 |
| miR-6125 | −1.47 | 0.1179 | −1.26 | 0.3307 | −1.01 | 0.9535 | −1.32 | 0.2461 |
| miR-8069 | 1.89 | 0.0006 | 1.44 | 0.0759 | 1.09 | 0.7352 | −1.53 | 0.0145 |
DaT DaT-SPECT imaging, L2NMC LRRK2 no manifesting carrier, L2PD LRRK2 carrier with symptomatic Parkinson disease, iPD idiopathic Parkinson disease, FC fold change, Adj. p FDR multiple-test adjusted p value.