Fig. 5.

NCATS-SM7270 is neuroprotective post-mTBI in NOX4 KO but not NOX1 or NOX2 KO mice. (A) Quantification of cell death in wild type mice or mice deficient in NOX1 (Panel A), NOX2 (Panel B), or NOX4 (Panel C) in the absence or presence of 40 μM NCATS-SM7270. Each symbol represents an individual mouse. All bar graphs represent 2 independent pooled experiments with 3–5 mice per group per experiment. Data were normalized to average DMSO or WT animal per experimental day and displayed as the mean fold change ±SD with *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, and ns ≥ 0.05 using Kruskal-Wallis with Dunn's multiple comparison test.