Table 3.
Results obtained with the expanded drug list.
| Drug | Albumin IC50 | ALT | Morphology | IF imaging | ||||
|---|---|---|---|---|---|---|---|---|
| Donor 1 | Donor 2 | Donor 1 | Donor 2 | Donor 1 | Donor 2 | Donor 1 | Donor 2 | |
| Asunaprevir | 190 | – | >1000 | – | 1000 | – | Apoptosis | – |
| Benoxaprofen | 8 | 20 | >100 | 100 | <0.1 | 100 | Apoptosis | Apoptosis |
| Beta-Estradiol | >300 | – | >300 | – | >300 | – | No findings | – |
| Chlorpheniramine | >300 | – | >300 | – | >300 | – | No findings | – |
| Diclofenac | 384 | – | >1000 | – | 1000 | – | Apoptosis | – |
| Labetalol | 26 | 40 | >100 | 100 | >100 | 100 | Apoptosis | Apoptosis |
| Lomitapide | 4 | – | >1000 | – | <0.1 | – | No findings | – |
| Simvastatin | <0.1 | <10 | >300 | >300 | >300 | >300 | No findings | Apoptosis |
| Stavudine | >60 | 132 | 300 | >300 | 300 | 300 | No findings | Mitotoxicity |
| Tacrine | 76 | >25 | >300 | >1000 | >300 | >1000 | Apoptosis | Apoptosis |
| Telithromycin | 13 | – | 30 | – | 100 | – | Apoptosis | – |
| Ximelagatran | 32 | >300 | 30 | >300 | 100 | 300 | No findings | No findings |
| Zileuton | >100 | 210 | >100 | >300 | >100 | >300 | No findings | No findings |