TABLE 4.
trans-acting factors known or thought to be involved in mRNA decay in S. cerevisiae
| Name | Function | Reference(s) |
|---|---|---|
| Enzymes involved in general decay | ||
| Xrn1p | 5′→3′ exonuclease (plus other functions) | 234, 520, 524 |
| Hke1p (Xrn2p) | 5′→3′ exonuclease (plus other functions) | 283, 521, 522, 525 |
| Dcp1p and Dcp2p | Decapping enzymes | 38, 311, 522 |
| Rrp41p/Ski6p | 3′→5′ exonuclease (5.8S rRNA processing) | 20, 379 |
| Other activities influencing decay | ||
| PAN | Pab1p-dependent poly(A) nuclease | 344, 475 |
| Ski2p, Ski3p, Ski8p | 20, 75 | |
| Mrt1p, Mrt3p | 204 | |
| Nonsense codon-dependent decay | ||
| Upf1p | Polysome-associated ATPase/helicase (interacts with eRF1 and eRF3) | 25, 105, 108, 108a, 131, 266, 322, 323, 584, 585 |
| Upf2p | Can bind other Upf proteins relatively strongly | 104, 107, 210, 266 |
| Upf3p | Predominantly nuclear (influences nuclear transport) | 25, 266, 321, 323 |