Table 2.
Immune cell composition of peripheral blood, bone marrow and spleen of NACL and ZOL-injected hu-BLT mice.
| Peripheral blood mononuclear cells | Bone marrow | Spleen | ||||
|---|---|---|---|---|---|---|
| Hu-BLT week 4 (n=2) | NACL | ZOL | NACL | ZOL | NACL | ZOL |
| % CD16+CD56+ | 7.4 | 9.1 | 2.9 | 8.7 | 1.9 | 3.7 |
| % CD3+ | 72 | 58 | 17 | 48 | 28 | 53 |
| % CD3+CD4+ | 67 | 88 | 73 | 62 | 77 | 84 |
| % CD3+CD8+ | 34 | 9 | 25 | 38 | 24 | 15 |
Hu-BLT mice were administered with either 0.9% NACL or ZOL (500 µg/kg) via IV as described in Materials and Methods section. Four weeks after injections, mice were euthanized and tissues were harvested to obtain single cell suspension. Immune cell composition was determined in PBMCs (n=2), bone marrow (n=2), and splenocytes (n=2) of hu-BLT mice using flow cytometric analysis.