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. 2023 Feb 2;13:1886. doi: 10.1038/s41598-023-28862-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Overview of enriched pathways by confirmed HILIC and C18 chromatography column metabolites that were significantly associated with infant age, identified using Metapone. Pathways with P ≥ 0.05 and weighted number of significant metabolites ≥ 1.5 are included. Point size indicates the number of significant metabolites identified within each pathway and point color indicates significance after adjustment for multiple testing via conditional local false discovery rate (lfdr). Pathways are grouped by super pathway (amino acid metabolism, bile acid, carbohydrate metabolism, lipid, and other), indicated by color.