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. 2023 Feb 2;14:558. doi: 10.1038/s41467-023-36315-4

Fig. 2. β-Aldh1a3 KO improves diabetic phenotypes.

Fig. 2

A Glucose levels in fasted and refed 12-week-old male mice (n = 5 mice per genotype). B IPGTT in 20-week-old mice (n = 5 per genotype). The P value was 1.6E–8, 1.0E–15, 2.6E–7, 3.3E–10, 1.0E–15, or 1.0E–15, for each time point in comparison of Aldh1a3 KO_db/db with db/db mice. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. C Plasma insulin levels in fasted and refed 12-week-old male mice (n = 5 per genotype). D Insulin secretion in islets from β-Aldh1a3 KO_db/db, lean or db/db mice. ANOVA was performed between the two groups (n = 8 per group). E Immunofluorescent staining of PDX1, INS, E-Cadherin and ALDH1A3 in β-Aldh1a3 KO_db/db or db/db mice. Representative immunofluorescence images of n = 3 mice per group. Scale bars: 50 μM. All data are expressed as means ± SEM. Two-way ANOVA with multiple comparison test was used for statistical analysis for (A–D). Source data are provided as a Source Data file.