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Endogenous formation of propionyl-CoA in R. eutropha R3, which has altered metabolism of the branched-chain amino acids. This mutant overproduces the acetolactate synthase approximately 15-fold to compensate for a defective threonine dehydratase. The endogenous accumulation of propionyl-CoA under nitrogen-limiting conditions allows this strain to produce P(3HB-3HV) without the supplementation of the growth medium with propionate or other cofeeds.
