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. 2023 Jan 20;14:1091807. doi: 10.3389/fmicb.2023.1091807

Figure 4.

Figure 4

Butyrate inhibits IFN and ISG via GPR43 in IPEC-J2 cells. (A) IPEC-J2 cells were treated with 1 mM butyrate and 500 nM GLPG0974 for 24 h and then infected with PEDV. IFNL1 levels in butyrate-treated and PEDV-infected IPEC-J2 cells were assessed after 24 h. (B) IPEC-J2 cells were transfected with FFAR2 shRNA plasmids and pretreated with butyrate for 24 h. IFNL1 levels in butyrate-treated and PEDV-infected IPEC-J2 cells were assessed after 24 h. (C) OAS1 gene expression in IPEC-J2 cells treated with 1 mM butyrate and 500 nM GLPG0974 and then infected with PEDV for 24 h.