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. 2023 Jan 20;14:1107559. doi: 10.3389/fimmu.2023.1107559

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Copyright © 2023 Zhang, Deng, Chen, Xu, Zhang, Chen, Zhang and Sun

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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EA and iPSC-EVs treatments modulated microbiota composition after cerebral ischemia−reperfusion. (A) The ASV/OTU number at each taxonomic level of phylum, class, order, family, genus, and species. The process used for species annotation involves comparing the data with a reference sequence database and scoring the results. (B) ASV/OTU Wayne diagram. To determine which species were common and which were unique among different samples (groups), ASV/OTU abundance tables were used to generate a Venn diagram. (C, D) Species composition taxon number statistics. (E, F) Taxonomic composition statistics at the phylum and species levels. (G) Akkermansia muciniphila flora abundance, n= 10/group, data wre expressed as the mean ± SD, *P < 0.05, **P < 0.01, and ***P < 0.001.