CLOTS Trial 3.

Trial name or title	CLOTS Trial 3
Methods	RCT
Participants	Country: UK Any patient admitted to hospital within 7 days of a clinical stroke
Interventions	IPC in addition to routine care versus routine care alone
Outcomes	Primary outcome: presence of definite or probable symptomatic or asymptomatic DVT in the popliteal or femoral veins detected on a screening CDU scan or any symptomatic DVT in the popliteal or femoral veins confirmed on CDU scan or contrast venography or MRI direct thrombus imaging within 30 days of randomisation Secondary outcomes: death within 30 days/6 months; presence of definite or probable DVT in the popliteal or femoral veins detected on a screening CDU scan or contrast venography or MRI direct thrombus imaging within 30 days of randomisation; definite symptomatic or asymptomatic DVT in the popliteal or femoral veins detected on either a CDU scan or contrast venography or MRI direct thrombus imaging within 30 days of randomisation; any definite or probable symptomatic or asymptomatic DVT; confirmed fatal or non‐fatal PE; adherence to allocated treatment; any confirmed symptomatic or asymptomatic DVT or PE occurring between randomisation and 6‐month follow up; any symptomatic DVT or PE occurring between randomisation and 6‐month follow up; place of residence at 6‐month follow up; post‐DVT syndrome; disability (modified Rankin score) at 6‐month follow up; health related quality of life (EuroQol) at 6‐month follow up
Starting date	2009
Contact information	Prof Martin Dennis, Department of Clinical Neurosciences, Western General Hospital, Edinburgh, EH4 2XU, UK
Notes

CDU: compression duplex ultrasound 
 DVT: deep vein thrombosis 
 IPC: intermittent pneumatic compression 
 MRI: magnetic resonance imaging 
 PE: pulmonary embolism 
 RCT: randomised controlled trial