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. 2022 Dec 2;83(3):363–373. doi: 10.1158/0008-5472.CAN-22-0074

Figure 2.

Figure 2. Cell-based exploration of IMMUcan scDB looking at B cells involvement in melanoma patients treated with anti–PD-1. A, UMAP plot of MEL_IMM_SS2_GSE120575 dataset. The cells are colored according to their major annotation. B, Bar plots of the percentage of cells per cell types in the whole dataset, and per response to treatment status. The cell types are colored according to the major annotation. C and D, Expression of MS4A1, a marker genes of B cells, visualized on a UMAP plot (C) and violin plot (D). Below violin plots are pie charts representing the proportion of expressing cells (“non-zero”) and below the absolute number. The colors correspond to major annotation. E, Table of the average expression of genes and differential expression of genes. Here, the top differentially expressed genes of B cells are ranked by descending average log2 fold change compared with the rest of the cells in the dataset.

Cell-based exploration of IMMUcan scDB looking at B cells involvement in melanoma patients treated with anti–PD-1. A, UMAP plot of MEL_IMM_SS2_GSE120575 dataset. The cells are colored according to their major annotation. B, Bar plots of the percentage of cells per cell types in the whole dataset and per response to treatment status. The cell types are colored according to the major annotation. C and D, Expression of MS4A1, a marker genes of B cells, visualized on a UMAP plot (C) and violin plot (D). Below violin plots are pie charts representing the proportion of expressing cells (“non-zero”) and below the absolute number. The colors correspond to major annotation. E, Table of the average expression of genes and differential expression of genes. Here, the top differentially expressed genes of B cells are ranked by descending average log2-fold change compared with the rest of the cells in the dataset.