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. 2022 Dec 2;83(3):363–373. doi: 10.1158/0008-5472.CAN-22-0074

Figure 4.

Figure 4. Transcriptional changes between normal and tumor-associated immune cells of 25 datasets from the IMMUcan scDB. A, Composition of CD8 (top) and CD4 (bottom) T-cell subtypes in normal tissue and TME. Every dot represents one dataset, the gray line represents samples from the same dataset. Paired Wilcoxon-ranked sum test, Bonferroni corrected. B, Top 10 upregulated and downregulated genes between normal and tumor-associated cells in a selection of cell types. Genes ranked by the average log2 fold change over all datasets and filtered for a prevalence of detection as differentially expressed gene in at least 20% of the datasets. C, Log normalized expression of SPP1 and APOE between macrophages from matched normal and tumor samples in four selected datasets.

Transcriptional changes between normal and tumor-associated immune cells of 25 datasets from the IMMUcan scDB. A, Composition of CD8 (top) and CD4 (bottom) T-cell subtypes in normal tissue and TME. Every dot represents one dataset, and the gray line represents samples from the same dataset. Paired Wilcoxon-ranked sum test, Bonferroni corrected. B, Top 10 upregulated and downregulated genes between normal and tumor-associated cells in a selection of cell types. Genes ranked by the average log2-fold change over all datasets and filtered for a prevalence of detection as differentially expressed gene in at least 20% of the datasets. C, Log normalized expression of SPP1 and APOE between macrophages from matched normal and tumor samples in four selected datasets. CRC, colorectal cancer.