Table 7.
Crude event rates of efficacy and safety outcomes in the BT arm of the six RCTs.
| DEVT7 | DIRECT-MT6 | DIRECT-SAFE10 | MR CLEAN-NO IV9 | SWIFT-DIRECT11 | SKIP8 | |
|---|---|---|---|---|---|---|
| 90-day mRS 0–2 | 55 (46.6) | 121 (36.8) | 88 (59.9) | 136 (51.1) | 135 (65.2) | 59 (57.3) |
| 90-day mRS 0–1 | 37 (31.4) | 74 (22.5) | 70 (47.6) | 41 (15.4) | 89 (43.0) | 46 (44.7) |
| 90-day mortality | 21 (17.8) | 62 (18.8) | 24 (16.3) | 42 (15.8) | 17 (8.2) | 9 (8.7) |
| Successful recanalization | 102 (86.4) | 267 (84.5) | 130 (89.0) | 196 (83.1) | 199 (96.1) | 96 (93.2) |
| sICH | 5 (4.3) | 20 (6.1) | 1 (0.7) | 14 (5.3) | 10 (4.9) | 8 (7.8) |
| Any ICH | 38 (32.5) | 139 (42.2) | 32 (21.8) | 85 (35.6) | 69 (33.7) | 52 (50.5) |
BT, Bridging Alteplase Therapy; DEVT, Direct Endovascular Thrombectomy Versus Combined IVT and Endovascular Thrombectomy for Patients With Acute Large Vessel Occlusion in the Anterior Circulation; DIRECT-MT, Direct Intraarterial Thrombectomy in Order to Revascularize Acute Ischemic Stroke Patients with Large Vessel Occlusion Efficiently in Chinese Tertiary Hospitals; DIRECT-SAFE, A Randomized Controlled Trial of DIRECT Endovascular Clot Retrieval Versus Standard Bridging Thrombolysis with Endovascular Clot Retrieval; MR CLEAN-NO IV, Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands; mRS, modified Rankin Scale; RCTs, randomized clinical controlled trials; sICH, symptomatic intracerebral hemorrhage; SKIP, Direct Mechanical Thrombectomy in Acute LVO Stroke; SWIFT-DIRECT, Solitaire with the Intention For Thrombectomy Plus Intravenous t-PA Versus DIRECT Solitaire Stent-retriever Thrombectomy in Acute Anterior Circulation Stroke.
Data are generally displayed as frequency with percentage (%) of patients.