Table 8.
Analysis to Find Baseline Characteristics That Are Predictive of Patients Self-reporting BII: Enterotoxins and Cytokines
| Baseline characteristic | Reference category | Cohort A vs Cohort B | Cohort A vs Cohort C | ||
|---|---|---|---|---|---|
| Odds ratio | P-value | Odds ratio | P-value | ||
| Enterotoxins | |||||
| ȃIgE anti-SEA (continuous) | — | 1.196 | 0.9600 | 126.899 | 0.4272 |
| ȃIgE anti-SEB (continuous) | — | 0.041 | 0.4948 | 0.167 | 0.6403 |
| ȃIgE anti-TSST (continuous) | — | 2.349 | 0.5323 | 0.618 | 0.6689 |
| ȃIgG anti-SEA (continuous) | — | 1.023 | 0.0973 | 1.052 | 0.0068 |
| ȃIgG anti-SEB (continuous) | — | 1.022 | 0.0551 | 1.017 | 0.1315 |
| ȃIgG anti-TSST (continuous) | — | 1.005 | 0.4630 | 1.007 | 0.3125 |
| Cytokines | |||||
| ȃElevated IL-5 (yes/no) | No | 1.363 | 0.6958 | 1.022 | 0.9762 |
| ȃElevated IL-13 (yes/no) | No | >999.999 | 0.0168 | 4.355 | 0.1956 |
| ȃElevated IL-2 (yes/no) | No | >999.999 | 0.0934 | >999.999 | 0.0911 |
| ȃElevated IL-6 (yes/no) | No | 1.000 | 1.0000 | 4.000 | 0.0945 |
| ȃElevated IL-9 (yes/no) | No | 2.042 | 0.5653 | >999.999 | 0.0911 |
| ȃElevated IL-10 (yes/no) | No | >999.999 | 0.0934 | >999.999 | 0.0911 |
| ȃElevated IFNγ (yes/no) | No | 1.000 | 1.0000 | 4.355 | 0.1956 |
| ȃElevated TNFα (yes/no) | No | 0.334 | 0.1228 | 1.022 | 0.9796 |
| ȃElevated IL-17A (yes/no) | No | >999.999 | 0.0392 | 3.196 | 0.3219 |
| ȃElevated IL-17F (yes/no) | No | 4.267 | 0.2020 | 4.355 | 0.1956 |
| ȃElevated IL-22 (yes/no) | No | >999.999 | 0.0392 | >999.999 | 0.0378 |
| ȃElevated IL-4 (yes/no) | No | 2.042 | 0.5653 | 1.021 | 0.9835 |
The odds ratios and P-values are from a logistic regression analysis with group as the dependent variable and the baseline characteristic as the explanatory variable. The P-value is for a 2-sided test of the null hypothesis that the true odds ratio equals 1. For enterotoxins, values of ‘<0.1’ (IgE) and ‘<2.0’ (IgG) have been converted to 0 for analysis. For cytokine values, when there was a discrepancy between readings of fluorescent intensity of separate samples in the initial analysis, the analysis was repeated, and most consistent values were used. BII, breast implant illness; IFN, interferon; Ig, immunoglobulin; IL, interleukin; TNF, tumor necrosis factor; SEA(B), Staphylococcus aureus enterotoxin A(B); TSST, toxic shock syndrome toxin.