TABLE 1.
Proteins containing cell wall sorting signals
| Source | Sequence of C-terminal sorting signala | Reference(s) |
|---|---|---|
| Actinomyces naeslundii | ||
| Fim P: type 1 fimbrial subunit (T14V) | LPLTGANGVIFLTIAGALLVAGGAVVAYANKRRHVAKH | 868 |
| Fim A: type 1 fimbrial subunit (T14V) | LPLTGANGMLILTASGASLLMIAVGSVLVARYRERKQNANLAL | 869 |
| Type 2 fimbrial subunit (WVU45) | LPLTGANGMLILTASGAALLMIAVGSVLVARYRERKRNRDLAA | 867 |
| Enterococcus faecalis | ||
| Asa1: aggregation substance | LPQTGEKQNVLLTVAGSLAAMLGLAGLGFKRRKETK | 237 |
| Asc10: aggregation substance | LPKTGEKQNVLLTVVGSLAAMLGLAGLGFKRRKETK | 411 |
| Asp1: aggregation substance | LPHTGEKENTLLSVLGAGMLAGLAWFGLKRKETEK | 236 |
| Sea1: surface exclusion protein | LPHTGEQKSIWLTIFGLFMAVGAISFKNKRRKNS | 840 |
| Sec10: surface exclusion protein | LPQTGEQQSIWLTIIGLLMAAGTINFKNKKRKKNS | 411 |
| PrgC: phermone-responsive surface protein | LPHTGEKFTLLFSVLGSFFVLISGFFFFKKNKKKA | 411, 571 |
| Unknown ORFb (hypothetical 30.5 kDa) | LPKTGETENIALSVLGSLMVLGSAFIFKKRI | 771 |
| Enterococcus faecium | ||
| Ash701: aggregation substance | LPQTGEKQNILLTVAGSLVTMLGLAGVGLKRRKETK | 315 |
| Lactococcus lactis | ||
| CluA: sex factor aggregation protein | LPKTGEGKAALAISIFGAALLGLAAYLKRNWIVSTYRKTVRKIRK | 271 |
| NisP: nisin serine protease | LPVTGDGEDFLPALGIVCISILGILKRKTKN | 810 |
| PrtP: casein serine protease | LPKTGETTERPAFGFLGVIVVSLMGVLGLKRKQREE | 820 |
| Lactobacillus paracasei | ||
| PrtP: casein serine protease | LPKTAETTERPAFGFLGVIVSLMGVLGLKRKQREE | 343 |
| Listeria monocytogenes | ||
| Internalin A | LPTTGDSDNALYLLLGLLAVGTAMALTKKARASK | 235 |
| Internalin C2 | LPTAGDENTMLPIFIGVFLLGTATLILRKTIKVK | 162 |
| Internalin D | LPTAGDENTMLPIFIGVFLLGTATLILRKTIKVK | 162 |
| Internalin E | LPITGDELNVLPIFVGAVLIGIGLVLFRKKRQTK | 162 |
| Internalin F | LPKTGDNAPWKTLFAGILLSSSAFYIWRKKA | 162 |
| Peptostreptococcus magnus | ||
| Protein L | LPKAGSEAEILTLAAAALSTAAGAYVSLKKRK | 412, 567 |
| PAB | LPEAGRRKAEILTLAAASLSSVAGAFISLKKRK | 141 |
| Streptococcus pyogenes (GAS) | ||
| C5A peptidase | LPTTNDKDTNRLHLLKLVMTTFFFGLVAHIFKTKRQKETKK | 118 |
| Trypsin-resistant surface protein (T6) | LPSTGSIGTYLFKAIGSAAMIGAIGIYIVKRRKA | 714 |
| SfbI/protein F | LPATGDIENVLAFLGILILSVLSIFSLLKNKQSNKKV | 720, 778 |
| SfbII/OF | LPASGDKREASFTIVALTIIGAAGLLSKKRRDTEEN | 448, 658 |
| M protein | ||
| Class I Emm (M6) | LPSTGETANPFFTAAALTVMATAGVAAVVKRKEEN | Table 2 |
| Class II Emm (Emm22) | LPSTGEAANPFFTAAAATVMVSAGMLALKRKEEN | Table 2 |
| Mrp/FcrA (Mrp8) | LPSTGEETTNPFFTAAALTVIASAGVLALKRKEEN | Table 2 |
| Enn (Enn49) | LPSTGEAANPFFTAAAATVMVSAGMLALKRKEEN | Table 2 |
| Unknown ORF | LPSTGEKAQPLFLATMTLMSLLGSLLVTKRQKETKK | 639 |
| Streptococcus agalactiae (GBS) | ||
| Alpha antigen | LPATGENATPFFNVAALTIISSVGLLSVSKKKED | 550 |
| Rib protein | LPATGENATPFFNVVALTIMSSVGLLSVSKKKED | 837 |
| Beta antigen (IgA Fc receptor) | LPYTGVASNLVLEIMGLLGLIGTSFIAMKRRKS | 319, 382 |
| C5a peptidase | LPTTNDKDTNRLHLLKLVMTTFFLGLVAHIFKTKRQKETKK | 119 |
| Streptococcus sp. (GCS and GGS) | ||
| Protein G (IgG binding) | LPTTGEGSNPFFTAAALAVMAGAGALAVASKRKED | 194, 290 |
| M protein (Group C) | LPSTGEATNPFFTAAALAVMATAGVAAVVKRKEEN | 776 |
| MIG (strain SC1) | LPTTGEGSNPFFTAAALAVMAGAGALAVASKRKED | 401 |
| MAG (strain 8215) | LPTTGEGSNPFFTAAALAVMAGAGALAVASKRKED | 399 |
| FnBA: fibronectin binding protein | LPQTGDTNKLETFFTITALTVIGAAGLLGKKRRNNQTD | 490 |
| FnBB: fibronectin binding protein | LPAAGEAEHVLSTIVGAMILFLVSLWGLLKRKASKA | 490 |
| GfbA: fibronectin binding protein | LPATGDIENVLAFLGILILSVLPIFSLLKNKQNNKV | 430 |
| Streptococcus gordonii | ||
| SspA/SSP-5 (antigen I/II) | LPKTGTNDSSYMPYLGLAALVGVLGLGQLKRKEDESK | 149 |
| SspB (antigen I/II) | LPKTGTNDATYMPYLGLAALVGFLGLGLAKRKED | 148, 149 |
| CshA | LPRTGSQTSDQTASGLLAAIASLTFFGLANRKKKSKED | 538, 539 |
| Streptococcus mutans | ||
| Antigen I/II (P1, B, PAc) | LPNTGVTNNAYMPLLGIIGLVTSFSLLGLKAKKD | 422, 423, 598 |
| β-d-Fructosidase | LPDTGDHKTDLSQLGVLAMIGSFLVEIASYFKKSKD | 103 |
| Dextranase | LPQTGDNNETRSNLLKVIGAGALLIGAAGLLSLIKGRKND | 363 |
| Glucan binding protein C | LPHTGAAKQNGLATLGAISTAFAAATLIAARKKEN | 704 |
| WapA | LPSTGEQAGLLLTTVGLVIVAVAGVYFYRTRR | 201 |
| Streptococcus pneumoniae | ||
| β-N-Acetylhexoseaminidase | LPETGTHDSAGLVVAGLMSTLAAYGLTKRKED | 122 |
| Neuraminidase | LPETGNKESDLLASLGLTAFFLGLFTLGKKREQ | 107 |
| Streptococcus sobrinus/downeii | ||
| SPAA (antigen I/II; PAg) | LPATGDSSNAYLPLLGLVSLTAGFSLLGLRRKQD | 794 |
| Dextranase | LPKTGDHKTVVLIIVLGLVFVGMTGLLARHEKK | 827 |
| Streptococcus equi | ||
| ZAG | LPTTGEKANPFFTAAALAIMAGAGALAVTSKRQQD | 400 |
| Fibronectin binding protein | LPQTSDMKQLTLSIIGAMSMLLVLCLSLFKRPSKKD | 491, 492 |
| SeM | LPSTGESANPFFTIAALTVIAGAGMAVVSPKRKEN | 784 |
| SzPW60 | LPSTGEATNPFFTAAALAVMAGAGVAAVSTRRKEN | 785 |
| SzPSe | LPSTGEATNPFFTAAALAVMAGAGVAAVSTRRKEN | 784 |
| Streptococcus suis | ||
| 136-kDa muramidase released surface protein | LPNTGEASSVAGALGTAMLVATLAFARKRRRNED | 747 |
| Staphylococcus aureus | ||
| Collagen adhesin | LPKTGMKIITSWITWVFIGILGLYLILRKRFNS | 626 |
| Fibrinogen binding protein (clumping factor) | LPDTGSEDEANTSLIWGLLASIGSLLLFRRKKENKDKK | 531 |
| FNBP: fibronectin binding protein | LPETGGEESTNKGMLFGGLFSILGLALLRRNKKNHKA | 727 |
| Protein A: IgG binding protein | LPETGEENPFIGTTVFGGLSLALGAALLAGRRREL | 726, 803 |
| Staphylococcus epidermidis | ||
| Fibrinogen binding protein | LPDTGANEDYGSKGTLLGTLFAGLGALLLGKRRKNRKNKN | 590 |
a
The LPXTG motif is shown in boldface type.
b
ORF, open reading frame.